| PROGRAMS |
RESEARCH PROGRAMS |
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This program is established to study the genetic constituents which determine the genome that yield the protein products of the genome. The understanding of the association of the genome and its proteomic may lead to the development of new diagnostics and therapeutic tools for diseases. Our objectives are (i) to study the correlation of the genes and the biological and external environment, (ii) to analyze the structures and functions of proteins encoded by the genes and (iii) to determine the role of genes and proteins in human as well as in animals. Our goals are (i) to isolate and identify gene and protein biomarkers in patients with disease (ii) to search for disease biomarkers and the role of the biomarkers during intervention. |
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This program focuses on the search for novel nutraceuticals and cosmeceuticals from natural bio-resources, particularly local resources in application for the maintenance of health, prevention and treatment of lifestyle diseases, including obesity, cardiovascular diseases, diabetes mellitus, colon cancer and Alzheimer’s disease. Novel bioactives for cosmeceuticals development with anti-aging functions are also studied. Investigation of mechanisms, genetic interactions and optimal delivery systems to target tissues and organs are carried out. |
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The majority of biopharmaceutical marketed to date are recombinant therapeutic protein drugs. Most of these proteins need to be reengineering in order to be fully employed as medicines. Unlocking and in silico analysis the atomic details of disease/target protein helps in tailoring designer proteins or peptides based therapeutics by biomimicking the binding/active sites, generate candidate molecules, check for their drug likeness, dock these molecules with the target, rank them according to their binding affinities, further optimize the molecules to improve binding characteristics. The stability and bioavailability of peptides based therapeutics can be overcome by forming cyclic end or peptidomimetics approaches. The aims of the program are:
1) to elucidate the structure and function of proteins;
2) to understand the behavior of proteins in silico; and
3) to engineer miniproteins or peptides based therapeutics. |
| Nanodelivery Research |
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| Coordinator : |
| Prof. Dr. Md. Zuki Abu Bakar |
| Tel |
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+603-8947 2102 |
| E-mail |
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zuki@ibs.upm.edu.my |
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| Members: |
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Nanodelivery Research Program is focusing on the applications of nanotechnology in improving the bioavailability and efficiency of uptake and transportation of nutra- and cosmeceutical bioactives to target tissue. Besides, this research program also actively involves in the innovation and pre-commercialization of nano-based nutricosmeceutical products for the prevention/treatment of aging and various degenerative diseases. |
